LEWOS BIOTECHNOLOGYNEUROSCIENCE · PRECLINICAL CROExplore · Discover · AdvanceNEUROPATHIC PAIN
Combine CCI, SNL and SNI models with mechanical, thermal and cold pain and tissue or molecular endpoints.
Pain readouts can be affected by motor capacity, stress and dosing itself. We track multiple sensory dimensions, screen for motor confounds and add DRG or spinal-cord tissue and molecular endpoints so behavioral improvement can be interpreted mechanistically.
For nerve-injury pain candidate screening, route comparison and pain-mechanism validation.
When a candidate enters analgesic screening; when dose, route or duration must be compared; or when behavioral improvement needs support from neural, inflammatory or target-level evidence.
01Which pain dimensions respond to the candidate?
02Does motor change confound sensory behavior?
03Do behavior, neural, inflammatory and target readouts agree?
Choose an experiment combination around the research question. Steps, groups and timing are confirmed per project.
Set model, groups, injury timing and baseline thresholds.
Track mechanical, thermal and cold pain after dosing.
Screen motor confounds and add DRG, spinal-cord or molecular assays as needed.
Compare pain and tissue endpoints across time, dose and groups.
See how models map to endpoints, then open the topic page for model scope and representative evidence.
DELIVERABLES
Deliverables are confirmed against the actual study scope and experiment combination.
Open the topics most directly related to this service for model scope and representative data.
Tell us your candidate type, study goal and development stage. We will help identify the experiment combination for Neuropathic pain efficacy.
