LEWOS BIOTECHNOLOGYNEUROSCIENCE · PRECLINICAL CROExplore · Discover · AdvanceEight platforms cover animal care, modeling and dosing, behavior, molecular analysis, pathology, imaging, electrophysiology and nucleic-acid screening. We combine primary endpoints, supporting readouts and collection windows around the candidate and research question.
Discuss a study need
01 / Animal care
Support disease-model husbandry and health monitoring throughout the study.
Schedule animal cohorts around model age, sex and observation windows to support dosing and phenotype assessment.
02 / Modeling & administration
Combine genetic, surgical and stress models with peripheral and CNS routes.
Match model establishment, intervention timing, dose and collection to the target and tissue; supports 13 routes and 50+ tissue types.
03 / Molecular analysis
Measure target genes, proteins and related molecular changes across delivery and efficacy endpoints.
Support target knockdown, protein expression, inflammation and mechanism studies, with LC-MS and GC-MS where needed.
04 / Histology & pathology
Assess tissue morphology, cellular localization and pathology burden.
Cover neurons, glia, protein aggregation and tissue injury, linking pathology to behavioral, molecular and delivery endpoints.
05 / Behavioral phenotyping
Cover cognition, motor function, sociability, emotion and sensory pain across 12 behavioral domains.
Build a phenotype battery around the disease question, control for motor confounds and support longitudinal tracking.
06 / Microscopy & imaging
Visualize brain regions, tissue and whole-body distribution with microscopy and live imaging.
Combine imaging methods for delivery distribution, regional structure and longitudinal observation.
07 / Electrophysiology & physiology
Connect neuronal activity, synaptic function and systemic physiology.
Combine excitability, synaptic transmission and plasticity readouts with project-specific physiological monitoring.
08 / Nucleic acid screening
Compare candidates, routes and target-tissue effects to support delivery selection.
Cover liver, muscle, brain, spinal cord, DRG, eye and ear studies, combining qPCR with pathology and distribution.
PLATFORM COMBINATIONS
Set primary endpoints, supporting readouts and collection windows during study design so results can be compared.
Let behavioral change and tissue or molecular change validate one another within the same study.
Combine brain distribution and quantitative endpoints to compare biological effect after delivery.
Compare sequences, carriers and dosing routes under consistent evaluation conditions.
Discuss your target, model or delivery question and learn about study plans, project scope and pricing.
