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Neuropathic pain
Neuropathic pain
Neuropathic pain follows peripheral or central sensitization after nerve injury and spans mechanical, thermal and cold hypersensitivity. Motor and stress effects should be controlled.
CCI, SNL and SNI provide complementary nerve-injury backgrounds and intervention windows. STZ, chemotherapy and CFA models can extend coverage to indication-specific pain mechanisms.
Pain studies combine blinded behavioral batteries with DRG electrophysiology, inflammatory markers and nociceptive-neuron histology to build a complete evidence chain.
- 6+Pain models
- 8Evaluation dimensions
- ≥85%Model success rate
- 4W+Stable window
Model strategy
Mechanical, thermal and cold pain with DRG / spinal-cord endpoints.
Match the model and study conditions to candidate mechanism, intervention stage and target tissue.
CCI
Chronic constriction injury
SNL
Spinal nerve ligation
SNI
Spared nerve injury
STZ / chemotherapy
Diabetic or chemotherapy-induced neuropathic pain
Evaluation endpoints
- 01Von Frey mechanical threshold
- 02Thermal and cold pain
- 03DRG electrophysiology and histology
- 04Inflammatory and target-gene / protein markers
Representative data
CCI model | Modeling and supporting evaluation workflow
A CCI evaluation workflow from pain threshold baseline and model establishment to multiple behavioral, molecular and pathological assays; it can be linked to long-term continuous pain threshold testing and supporting analyses.
CCI model | Changes in mechanical and thermal pain thresholds
Von Frey mechanical pain threshold and Hargreaves thermal pain latency curves for the Sham and CCI Model groups from −1 to 13 days after surgery; pain thresholds in the model group were persistently reduced.
Technical contact
Discuss your target, model or delivery question and learn about study plans, project scope and pricing.