01Why · Target
Causes
Target & mechanism
Define the disease mechanism and translational objective a candidate is designed to address.
LEWOS BIOTECHNOLOGYNEUROSCIENCE · PRECLINICAL CROExplore · Discover · AdvanceA next-generation neuroscience CRO partner
Neurological disease preclinical efficacy
From target mechanism and disease models to delivery and multidimensional endpoints, we build preclinical evidence that can be tested, interpreted and advanced.
200+Completed projects
8Integrated platforms
7Neuroscience PhDs
80+High-impact papers
≥80%Model success rate
4C scientific decision
Translate four scientific questions—cause, mechanism, manifestation and treatment choice—into target, model, endpoint and dosing decisions.
PhD-led · Co-designed · Interpreted together02How · Model
Core mechanisms
Best-fit model
Match disease stage, animal background and intervention window.
03What · Endpoints
Clinical manifestation
Core endpoints
Combine behavioral, molecular, histology, imaging and electrophysiology readouts.
04Where · Route
Cure choice
Dosing strategy
Design the route, dose frequency and tissue-distribution validation.
Core services
From disease mechanisms and model building to CNS delivery, efficacy endpoints and multidimensional validation, we support the next decision for each candidate.
01CNS EFFICACY
CNS disease models & efficacy
Neurodegeneration, neurodevelopment, psychiatric disease, stroke, traumatic brain injury, epilepsy and related CNS indications.
02NEUROPATHIC PAIN
Neuropathic pain efficacy
CCI, SNL and SNI models combined with mechanical, thermal and cold pain, histology and molecular endpoints.
03BBB DELIVERY
hTFR macromolecule brain delivery
Delivery evaluation for anti-human TfR1 antibodies, bispecifics, AOCs, ADCs and other protein therapeutics.
04NUCLEIC ACID
Nucleic acid delivery & efficacy
Compare siRNA, ASO, mRNA and LNP candidates across routes, tissue distribution and expression or knockdown.
Models & evidence
Explore models, endpoints and representative data by research area.
View all models & evidenceAD · Alzheimer’s disease
Alzheimer's disease
Representative models
- 5xFAD
- rTg4510
- APP/PS1
- P301S
Aβ / Tau pathology, neuroinflammation and cognition.
View model & endpoint detailsPD · Parkinson’s disease
Parkinson's disease
Representative models
- A53T
- MPTP
- PFFs
- 6-OHDA
α-syn, TH+ neurons and motor-function assessment.
View model & endpoint detailsALS · Amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis
Representative models
- SOD1-G93A
- TDP-43
Motor function, body weight, survival and neuromuscular pathology.
View model & endpoint detailsBrowse more models horizontallyDiscuss your model needs
Integrated platforms
Eight platforms connect animal care, modeling, dosing and multidimensional analysis for neuroscience studies.
Explore platform capabilities01
SPF IVC animal care
Animal careSupport disease-model husbandry and health monitoring throughout the study.
SPF IVC housing · Body weight & condition · Age-window tracking02
Modeling & precision dosing
Modeling & administrationCombine genetic, surgical and stress models with peripheral and CNS routes.
ICV / P0 ICV · IT / IV / SC · Stereotaxic injection03
Molecular analysis
Molecular analysisMeasure target genes, proteins and related molecular changes across delivery and efficacy endpoints.
qPCR / RT-PCR · Western blot · ELISA04
Histology & pathology
Histology & pathologyAssess tissue morphology, cellular localization and pathology burden.
Paraffin / frozen / vibratome sections · IHC / IF · RNAscope05
Behavioral phenotyping
Behavioral phenotypingCover cognition, motor function, sociability, emotion and sensory pain across 12 behavioral domains.
Morris water maze / Y-maze · Three-chamber social · Rotarod / grip / beam walk06
Microscopy & live imaging
Microscopy & imagingVisualize brain regions, tissue and whole-body distribution with microscopy and live imaging.
Fluorescence microscopy · Optical imaging · MRI / CT07
Electrophysiology & physiology
Electrophysiology & physiologyConnect neuronal activity, synaptic function and systemic physiology.
Action potential / membrane potential · mEPSC / mIPSC · LTP / LTD / fEPSPs08
Nucleic acid delivery screening
Nucleic acid screeningCompare candidates, routes and target-tissue effects to support delivery selection.
siRNA / ASO / mRNA · Peripheral and CNS dosing · Multi-tissue quantification13Dosing routes
50+Tissue types
10Molecular assays
9Imaging methods
11Electrophysiology & physiology
12Behavioral domains
Collaboration network
We work with universities, hospitals and biopharma teams to support study validation, pipeline progress and translation.
Universities & research institutes
Hospitals
Industry & specialist organisations
How we work
Bring a target, candidate or development question. We turn it into an executable model, endpoint and data-delivery plan.
01Deep consultationAlign target, mechanism and development stage
02Study designConfirm model, endpoints, route and scope
03Expert executionPhD oversight, SOPs and process records
04Data deliveryInterpretation and next-step recommendations
Technical contact
Discuss your target, model or delivery question and learn about study plans, project scope and pricing.